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KMID : 1041220040460010023
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Journal of Sericultural and Entomological Science
2004 Volume.46 No. 1 p.23 ~ p.27
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Cognitive Ability Enhancement Effects in Rats by B. mori Fibroin Enzymatic Hydrolysate
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Yeo Joo-Hong
Lee Kwang-Gill
Lee Yong-Woo
Han Sang-Mi
Woo Soon-Ok
Kwon Hae-Yong
Kim Jin-Il
Kim Sung-Su
Demura Makoto
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Abstract
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We were investigated the cognitive ability enhancement in rats using B. mori fibroin molecular controlled hydrolysate by preparative recycle HPLC system. Also, some of its physicochemical properties and free amino acid components were investigated, too. Nuclear magnetic resonance (NMR) spectrum are measured different pattern between high (HF) and low (LF) molecular controlled B. mori fibroin samples, respectively. The in vitro test by neuron primary cell culture are showed dependent on molecular weight (Mw) of B. mori fibroin in the order of LF > MF > HF, too. However, the memorial effects in rats by in vivo test are large dependent molecular weight on that maximum 50% than control. Also, the memorial effect was higher than the enzymatic relative and acid hydrolysate, which was 50.0$\pm$2.1 and 25.9$\pm$0.32%, respectively.
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KEYWORD
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Silk fibroin hydrolysate, memorial growth effect, NMR
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